diff --git a/Lib/configparser.py b/Lib/configparser.py
index 3c452afe8ade485..26207fbbdaaf458 100644
--- a/Lib/configparser.py
+++ b/Lib/configparser.py
@@ -618,7 +618,7 @@ class RawConfigParser(MutableMapping):
     _OPT_TMPL = r"""
         (?P<option>                        # very permissive!
             (?:(?!{delim})\S)*             # non-delimiter non-whitespace
-            (?:\s+(?:(?!{delim})\S)+)*)    # optionally more words
+            (?:(?:(?!{delim})\s)+(?:(?!{delim})\S)+)*)    # optionally more words
         \s*(?P<vi>{delim})\s*              # any number of space/tab,
                                            # followed by any of the
                                            # allowed delimiters,
@@ -628,7 +628,7 @@ class RawConfigParser(MutableMapping):
     _OPT_NV_TMPL = r"""
         (?P<option>                        # very permissive!
             (?:(?!{delim})\S)*             # non-delimiter non-whitespace
-            (?:\s+(?:(?!{delim})\S)+)*)    # optionally more words
+            (?:(?:(?!{delim})\s)+(?:(?!{delim})\S)+)*)    # optionally more words
         \s*(?:                             # any number of space/tab,
         (?P<vi>{delim})\s*                 # optionally followed by
                                            # any of the allowed
diff --git a/Lib/test/test_configparser.py b/Lib/test/test_configparser.py
index 4783943f71a1092..7f0399fd59b96a0 100644
--- a/Lib/test/test_configparser.py
+++ b/Lib/test/test_configparser.py
@@ -43,7 +43,7 @@ class CfgParserTestCaseClass:
     default_section = configparser.DEFAULTSECT
     interpolation = configparser._UNSET
 
-    def newconfig(self, defaults=None):
+    def newconfig(self, defaults=None, **kwargs):
         arguments = dict(
             defaults=defaults,
             allow_no_value=self.allow_no_value,
@@ -56,6 +56,7 @@ def newconfig(self, defaults=None):
             default_section=self.default_section,
             interpolation=self.interpolation,
         )
+        arguments.update(kwargs)
         instance = self.config_class(**arguments)
         return instance
 
@@ -358,6 +359,13 @@ def test_basic(self):
                 the larch {0[1]} 1
             """.format(self.delimiters)))
 
+    def test_space_delimiter(self):
+        # gh-156353: Space should be accepted as a delimiter
+        cf = self.newconfig(delimiters=(' ', '='))
+        cf.read_string("[all]\nfoo bar=baz")
+        self.assertEqual(cf.options('all'), ['foo'])
+        self.assertEqual(cf.get('all', 'foo'), 'bar=baz')
+
     def test_basic_from_dict(self):
         config = {
             "Foo Bar": {
@@ -1991,8 +1999,8 @@ class ConvertersTestCase(BasicTestCase, unittest.TestCase):
 
     config_class = configparser.ConfigParser
 
-    def newconfig(self, defaults=None):
-        instance = super().newconfig(defaults=defaults)
+    def newconfig(self, defaults=None, **kwargs):
+        instance = super().newconfig(defaults=defaults, **kwargs)
         instance.converters['list'] = lambda v: [e.strip() for e in v.split()
                                                  if e.strip()]
         return instance
diff --git a/Misc/NEWS.d/next/Library/2026-08-26-02-30-00.gh-issue-156353.abcdef.rst b/Misc/NEWS.d/next/Library/2026-08-26-02-30-00.gh-issue-156353.abcdef.rst
new file mode 100644
index 000000000000000..9c93abb260e288e
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2026-08-26-02-30-00.gh-issue-156353.abcdef.rst
@@ -0,0 +1 @@
+Fix :mod:`configparser` space delimiter parsing when using ``delimiters=(' ', '=')``.