diff --git a/src/pendulum/tz/timezone.py b/src/pendulum/tz/timezone.py
index e46e13df..1dd7ac3d 100644
--- a/src/pendulum/tz/timezone.py
+++ b/src/pendulum/tz/timezone.py
@@ -2,11 +2,13 @@
 from __future__ import annotations
 
 import datetime as _datetime
+import io
 import zoneinfo
 
 from abc import ABC
 from abc import abstractmethod
 from typing import TYPE_CHECKING
+from typing import Any
 from typing import TypeVar
 from typing import cast
 
@@ -16,6 +18,9 @@
 
 
 if TYPE_CHECKING:
+    from collections.abc import Callable
+    from zoneinfo._common import _IOBytes
+
     from typing_extensions import Self
 
 POST_TRANSITION = "post"
@@ -60,12 +65,46 @@ class Timezone(zoneinfo.ZoneInfo, PendulumTimezone):
     >>> tz = Timezone('Europe/Paris')
     """
 
+    _file_bytes: bytes | None = None
+
     def __new__(cls, key: str) -> Self:
         try:
             return super().__new__(cls, key)  # type: ignore[call-arg]
         except zoneinfo.ZoneInfoNotFoundError:
             raise InvalidTimezone(key)
 
+    @classmethod
+    def from_file(cls, fobj: _IOBytes, /, key: str | None = None) -> Self:
+        # The underlying zoneinfo.ZoneInfo.from_file() refuses to pickle any
+        # instance built this way, key or no key, since it has no record of
+        # which file it came from to reconstruct on unpickling. That's the
+        # path get_local_timezone() falls back to when the system's local
+        # timezone can't be identified by name (no /etc/timezone, no readable
+        # /etc/localtime symlink, etc.), so keep the raw TZif bytes around and
+        # use them to rebuild an equivalent instance if this ever needs to be
+        # pickled instead.
+        data = fobj.read(-1)
+        instance = cast("Self", super().from_file(io.BytesIO(data), key=key))
+        instance._file_bytes = data
+
+        return instance
+
+    def __reduce__(
+        self,
+    ) -> (
+        tuple[Callable[[bytes, str | None], Self], tuple[bytes, str | None]]
+        | str
+        | tuple[Any, ...]
+    ):
+        if self._file_bytes is None:
+            return super().__reduce__()
+
+        return self.__class__._from_pickled_file, (self._file_bytes, self.key)
+
+    @classmethod
+    def _from_pickled_file(cls, data: bytes, key: str | None) -> Self:
+        return cls.from_file(io.BytesIO(data), key=key)
+
     def __eq__(self, other: object) -> bool:
         return isinstance(other, Timezone) and self.key == other.key
 
diff --git a/tests/tz/test_timezone.py b/tests/tz/test_timezone.py
index 3f090168..f4e41ec6 100644
--- a/tests/tz/test_timezone.py
+++ b/tests/tz/test_timezone.py
@@ -1,5 +1,6 @@
 from __future__ import annotations
 
+import pickle
 import zoneinfo
 
 from datetime import datetime
@@ -462,3 +463,48 @@ def test_repr():
     tz = timezone("Europe/Paris")
 
     assert repr(tz) == "Timezone('Europe/Paris')"
+
+
+def _paris_tzif_bytes() -> bytes:
+    # tzdata bundles the same IANA zoneinfo files the system copy under
+    # /usr/share/zoneinfo would have, in a location that works on every
+    # platform pendulum supports (including Windows, which has no system
+    # zoneinfo directory at all).
+    from importlib import resources
+
+    return resources.files("tzdata.zoneinfo").joinpath("Europe", "Paris").read_bytes()
+
+
+def test_from_file_without_a_key_can_be_pickled():
+    # get_local_timezone()'s last-resort fallback (no /etc/timezone, no
+    # readable /etc/localtime symlink to derive a name from) reads the raw
+    # zoneinfo file and builds a Timezone this same way, with no key.
+    from io import BytesIO
+
+    import pendulum.tz.timezone as timezone_module
+
+    tz = timezone_module.Timezone.from_file(BytesIO(_paris_tzif_bytes()))
+
+    assert tz.key is None
+
+    unpickled = pickle.loads(pickle.dumps(tz))
+
+    assert unpickled.key is None
+    dt = datetime(2024, 7, 1, 12, tzinfo=unpickled)
+    assert dt.utcoffset() == timedelta(hours=2)  # CEST, matches Europe/Paris in July
+    dt = datetime(2024, 1, 1, 12, tzinfo=unpickled)
+    assert dt.utcoffset() == timedelta(hours=1)  # CET, matches Europe/Paris in January
+
+
+def test_from_file_with_a_key_still_pickles_by_key():
+    from io import BytesIO
+
+    import pendulum.tz.timezone as timezone_module
+
+    tz = timezone_module.Timezone.from_file(
+        BytesIO(_paris_tzif_bytes()), key="Europe/Paris"
+    )
+
+    unpickled = pickle.loads(pickle.dumps(tz))
+
+    assert unpickled.key == "Europe/Paris"